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Invokana (canagliflozin) Invokana (canagliflozin), an SGLT2 inhibitor, is now a first-line option for Type 2 diabetes patients with cardiovascular disease, high cardiovascular risk, heart failure, or chronic kidney disease (CKD), regardless of baseline A1C, according to the 2022 American Diabetes Association (ADA) Standards of Care in Diabetes
